Abstract

Diabetes affects millions in the US, causing elevated blood glucose levels that could lead to complications like kidney failure and heart disease. Recent development of continuous glucose monitors has enabled a minimally invasive option, but the discomfort and social factors highlight the need for noninvasive alternatives in diabetes management. We propose a portable noninvasive glucose sensing system based on the glucose’s optical activity property which rotates linearly polarized light depending on its concentration level. To enable a portable form factor, a light trap mechanism is used to capture unwanted specular reflection from the palm and the enclosure itself. We fabricate four sensing prototypes and conduct a 363-day multi-session clinical evaluation in real-world settings. 30 participants are provided with a prototype for a 5-day home monitoring study, collecting on average 8 data points per day. We identify the error caused by differences between the sensing boxes and the participants’ improper usage. We utilize a machine learning pipeline together with Bayesian Ridge Regressor models and multiple-step data processing techniques to deal with the noisy data. Over 95% of the predictions fall within Zone A (clinically accurate) or B (clinically acceptable) of the Consensus Error Grid with a 0.24 mean absolute relative differences.
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Noninvasive Glucose Monitoring Using Polarized Light
Published
,
2020
Tianxing Li, Derek Bai, Temiloluwa Prioleau, Nam Bui, Tam Vu, Xia. Zhou
We propose a compact noninvasive glucose monitoring system using polarized light, where a user simply needs to place his/her palm on the device for measuring his/her current glucose concentration level.

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